The guide RNA and the Cas9 protein complex together go bouncing along the genome, and when they find a spot where the guide RNA matches, then it inserts between the two strands of the double helix, it rips them apart, that triggers the Cas9 protein to cut, and all of a sudden, you've got a cell that's in total panic because now it's got a piece of DNA that's broken.
Vodička RNK i Cas9 kompleks bjelančevina skupa skakuću po genomu, i kada nađu mjesto na koje pristaje RNK, umeće se između dvije niti dvostruke uzvojnice, kida ih, i to uzrokuje da Cas9 bjelančevina reže, i odjednom, imate stanicu koja je u panici jer sada ima komad pokidane DNK.