This triggers the pituitary gland, a pea-sized gland found at the base of the brain, to release adrenocorticotropic hormone which then stimulates the adrenal gland sitting on top of the kidneys to release cortisol, the major stress hormone.
Time se pokreće hipofiza, žlijezda veličine graška  s donje strane mozga, koja zatim oslobađa  adrenokortikotropni hormon, a on potiče nadbubrežnu žlijezdu da izluči kortizol, važni hormon stresa.